Projects.

• Interoperable IT infrastructure for French Bilogical Resource Centers (biobank) (I3-CRB project - French BRCs directory).
• Biological databases development.
  • The hepatitis B Virus database (HBVdb) (PI, with J. Hayer)
  • The BCL-2 family database (Bcl2db) (co-worker, with S. Blaineau and Dr A. Aouacheria)
  • The Bacterial Tyrosin Kinase database (BYKdb) (PI, with F. Jadeau and Dr C. Grangeasse, BACTYRKIN ANR project)
  • The European Hepatitis C Virus database (euHCVdb) as part of EU FP5 HepCVax and EU FP6 VIRGIL NoE (PI, with J. Lopez, C. Charavay, D. Crisan, D. Grando, N. Garnier, Dr F. Dorkeld, Dr E. Bettler and Dr C. Geourjon)
  • The ViralORFeome project (particpant)
  • Query biological database system (QueBio): a biological database query system based on the Structured Query Language (SQL) (PI, with J. Lopez, C. Charavay, D. Crisan, D. Grando)
• Protein sequence/structure/function analysis and Web services for biologists.
  • NPS@ web server: integrated protein sequence analysis distributed on a cluster of computers (ACI IMPbio, with D. Grando)
  • Geno3D web server automatic protein structure prediction server (with Dr C. Geourjon)
  • SuMo web server for 3D search of functional sites in proteins (with M. Jambon and Dr C. Geourjon)
• Applied bioinformatics.
  • Analysis of HCV core alternate reading frames (with M. Ratinier and Dr J.P. Lavergne)
  • Understanding and predicting the viral resistances to drugs of the HCV NS3 protease (with M. Chatron, L. Barbotte, Dr R. Terreux)
  • Analysis of the HCV E2 glycoprotein HVR1 sequences (with Pr. JM Pawlotsky and Dr F. Penin).
  • Molecular modeling of HIV GP41 trasmembrane protein (done during my master) (French only).