Research > Field

My research activity deals with structural bioinformatics that I have introduced in Lyon since 1986 (more than 20 years ago, the word did not exist...). Indeed, at that time one considered informatics applied to biology even ANalyze THE PROTeins :-) . Since 15 years I am responsible of the structural bioinformatics group from the Structural Bioinformatics and NMR at the IBCP.

 Development of methods for analyzing and predicting the secondary structure of proteins.
More than 15 original methods among the [Double Prédiction Method, 1987], [Self Optimised Prédiction Method, 1994], [Self Optimised Prédiction Method from Alignments, 1995] each of them collecting more than 200 citations.

 Development of software for analyzing the 1D, 2D, 3D structure of proteins.
[ANTHEPROT, 1988-2001]. It has to be noticed that this software was the first in its category (with PC/Gene from Amos Bairoch). About 250 citations, more than 10000 downloads, and more than 1500 analysis requests done per year.
[DicroProt, 1993]. 1000 downloads and 130 citations

  Methods integration and web server developmment.
I have developed the first french mailserver with the help of C. Geourjon fro predicting the secondary structure of proteins (80 000 predictions). Then, I have integrated the methods in the first release of [NPS@ server 2000]. C. Combet has maintained and developed the next release (more than 630 citations for the publication, more than 6000 analyzes per day in 2009, more than 12 000 000 analyzes in 10 years).

  Viral bioinformatics
At the very beginning of the structural virology, it was obvious that the development of virla database was a requisite necessity. Thus, the HCVDB database (PHD work of C. Combet) was initiated in France (french Hepatitis national Network) then extended in the context of a european contract of FP5 [HepCVax] in a workpackage thta I ccordinated. The euHCVdb database set up by C. Combet comprises more than 80 000 sequences of hepatitis C virus.

  Biology application
The bioinformatics methods have to be usable by biologists. That is why tools and methods have been applied in collaboration with biologists groups in several fields (immunology, virology, molecular biology, structural biology, microbiology).

The group of structural Bioinformatics (see publications related to this field) has several research areas:
  GRID computing [C. Blanchet]
  Molecular modelling [C. Geourjon]
  Methods integration[C. Combet]
  3D Web server [E. Bettler]
  Drug design and QSAR (R. Terreux)
  Molecular interactions (R. Lavery & K. Zakrewska)

3 people connected   121209 visits
Jeudi 17 mai 2012 : 17:58  69.8 °F
Your IP address: 38.107.179.236
© GD-1993-2012